Appearance:

Crystals appear as a combination of sickle cells and hemoglobin C crystals. They are dark red inclusions with blunt ended projections.¹ The crystals are longer than Hemoglobin C crystals, but shorter and thicker than Hemoglobin S.

Inclusion composition:¹

Hemoglobin S and hemoglobin C

Associated Disease/Clinical States:¹

Hemoglobin SC Disease (compound heterozygosity)

References:

1. Rodak BF, Carr JH. Variations in shape and distribution of  erythrocytes. In: Clinical hematology atlas. 5th ed. St. Louis, Missouri: Elsevier Inc.; 2017. p. 93-106.