Sublingual (SL) administration

Administration of a drug by dissolving a tablet underneath the tongue, so that drug is absorbed directly into the systemic circulation, thereby avoiding the first pass effect. If a portion of a drug administered as a sublingual tablet is inadvertently swallowed in saliva, that portion of the drug dose will then be subjected to first pass metabolism.

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An ABC of PK/PD Copyright © 2023 by Dr. Andrew Holt is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.

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