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Dedication
Foreword from Dr. Terry Hébert
About the authors
Introduction
Acknowledgements
A+B Intercept
Absorption
Acetylation
ADME
Alpha (α) rate constant
Apparent volume of distribution
Area under the curve
Beta (β) rate constant
B-Intercept
Bioavailability
Buccal (BUC) administration
Central compartment
Clearance
Clearance by glomerular filtration
Clearance by secretion
Cmax (and Cmin)
Compartmental pharmacokinetics
Conjugation
Context-sensitive half-time
Concentration (of drug) in the plasma at t=0
Creatinine clearance
Cytochrome P450 (CYP) enzymes
Distribution
Dose-dependent kinetics
Dosing rate
Elimination
Enteral (administration)
Equilibration
Exponential curve
Extensive metaboliser
Extraction ratio
Fick's Law of Diffusion
First-order elimination
First-order elimination rate constant
First-pass metabolism
Formulation
Glucuronidation
Glutathione conjugation
Half-life of distribution
Half-life of elimination
Henderson-Hasselbalch equation
Hepatic clearance
Hepatic extraction ratio
High hepatic extraction ratio drug
Hockey stick curve
Intravenous (IV) administration
Intrinsic clearance
Ionisation (of a drug)
Lipid solubility
Loading dose
Low hepatic extraction ratio drug
Lymphatic drug absorption
Metabolism
Monograph
One compartment drug
Oral (PO) administration
Oral bioavailability
Parenteral (administration)
Phase I metabolism
Phase II metabolism
pKa
Plasma protein binding
Poor metaboliser
Rapid metaboliser
Reabsorption (from filtrate)
Rectal (PR) administration
Renal clearance
Repeated dosing calculations
Steady state concentration
Sublingual (SL) administration
Sulfation
Terminal elimination phase
Therapeutic drug monitoring
Therapeutic index
Therapeutic window
Three compartment drug
Tissue compartment
t max
Topical
Topological polar surface area
Total body clearance
Two compartment drug
Type A adverse drug reaction
Type B adverse drug reaction
Volume of distribution
Weak acid
Weak base
Zero order elimination
Affinity
Agonist
Allosteric (effect)
Allosteric modulator
Antagonist
Association
Binding
Competition
Desensitisation (to drug effect)
Dissociation
Drug
Efficacy
Equilibrium dissociation constant
Hill-Langmuir equation
Hyperbola
Ligand
Off-target side-effects
On-target side-effects
Partial agonist
Selectivity
Sigmoid
Spare receptors
CC1 - Drug targets
CC2 - Drug-target interaction
CC3 - Structure-activity relationship
CC4 - Mechanism of drug action
CC5 - Dose/concentration-response relationship
CC6 - Drug affinity
CC7 - Drug efficacy
CC8 - Drug potency
CC9 - Drug selectivity
CC10 - Drug absorption
CC11 - Drug bioavailability
CC12 - Drug distribution
CC13 - Volume of distribution
CC14 - Drug metabolism
CC15 - First- and zero-order kinetics
CC16 - Drug elimination
CC17 - Drug elimination half-life
CC18 - Drug clearance
CC19 - Steady-state concentration
CC20 - Drug tolerance
CC21 - Adverse drug reaction and adverse drug event
CC22 - Therapeutic index
CC23 - Drug interaction
CC24 - Individual variation
Suggested reading
The term used to refer to any small molecule that binds to a protein to form a complex.
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An ABC of PK/PD Copyright © 2023 by Dr. Andrew Holt is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.