CC7 – Drug efficacy
CC7. Drug efficacy is the ability of a drug to elicit a response once bound to a drug target.
7.1. Efficacy depends on the drug’s ability to favour stabilisation of active conformational states of the agonist-bound receptor.
7.2. Different agonists will produce varying levels of response: Full agonist (maximal response), partial agonists (sub-maximal response) and inverse agonists (suppress basal constitutive response).
7.3. A drug’s maximum response can change as a consequence of the binding of an allosteric modulator.
