CC20 – Drug tolerance

CC20. Drug tolerance is the diminished response to a drug following repeated or prolonged exposure.

20.1. Drug tolerance may occur through pharmacodynamic and/or pharmacokinetic mechanisms.

20.2. Drug tolerance can occur at a molecular or a systemic level.

20.3. When drug tolerance occurs, increasing concentrations of the drug will be required to evoke the same biological or clinical effect.

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An ABC of PK/PD Copyright © 2023 by Dr. Andrew Holt is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted.

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