CC14 – Drug metabolism
CC14. Drug metabolism is the chemical transformation of a drug into one or more products within the body.
14.1. Drug metabolism generates products (metabolites) that have their own chemical properties and may be biologically active or inert.
14.2. Drug metabolism does not occur for all drugs.
14.3. Drug metabolism can be mediated by enzymes and involves reactions such as oxidation, reduction, hydrolysis and/or conjugation.
14.4. Drug metabolism can be modified by endogenous and exogenous factors such as genetics, disease states and xenobiotics.
14.5. Drug metabolism can alter the biological activity of a drug, terminate its action and facilitate its excretion.
